New Research Supports Use of St. John’s Wort for Relieving Depression
Tuesday, October 28th, 2008 | Author: Organic Health News

For centuries our ancestors have used a plant known as Hypericum perforatum, commonly referred to as St. John’s Wort, as an herbal remedy for many ailments, including mental disorders, diarrhea, nausea, ulcers and sleep disorders. But St. John’s Wort is most commonly known as a natural, herbal remedy for those suffering symptoms of depression and anxiety.
According to new research published in The Cochrane Database of Systematic Reviews, St. John’s Wort is effective at treating major symptoms of depression. This new research backs up previous research conducted in 2005, that came to the same conclusions.
In one of the most comprehensive clinical studies of St. John’s Wort to date, researchers studied 5,489 patients suffering symptoms of major depression. Administering both placebos and St. John’s Wort extract to patients, researchers came to the conclusion that St. John’s Wort was more effective than the placebo at treating mild to major cases of depression.
List of Clinical Studies for St. John’s Wort
This isn’t the first clinical study investigating the effectiveness of St. John’s Wort for symptoms of depression. In fact, here is a short list of studies done within the last fifteen years.
- St John’s Wort For Depression — An Overview & Meta-Analysis of Randomised Clinical Trials
- St. John’s Wort in Mild to Moderate Depression: The Relevance of Hyperforin for the Clinical Efficacy
- St. John’s Wort For Depression: A Meta-Analysis of Well-Defined Clinical Trials
- Comparison of Equivalence Between the St. John’s Wort Extract LoHyp-57 and Fluoxetine
- Hypericum Extract versus Imipramine or Placebo in Patients with Moderate Depression: Randomised Multicentre Study of Treatment for Eight Weeks
- Equivalence of St John’s Wort Extract (Ze 117) and Fluoxetine: A Randomized, Controlled Study in Mild-Moderate Depression
- Efficacy of St. John’s Wort Extract WS 5570 in Major Depression: A Double-Blind, Placebo-Controlled Trial
- Acute Treatment of Moderate to Severe Depression with Hypericum Extract WS 5570 (St John’s wort): Randomised Controlled Double Blind Non-Inferiority Trial versus Paroxetine.
- The Efficacy of St. John’s Wort in Patients with Minor Depressive Symptoms or Dysthymia — A Double-Blind Placebo-Controlled Study
It must be noted that while there is overwhelming evidence supporting the use of Hypericum perforatum, there has been a few studies with different conclusions. In fact, one major study conducted by the National Institues of Health found that St. John’s Wort made no positive impact on patients suffering from major depression.
Possible Side Effects of St. John’s Wort

It is not uncommon for people to suffer small side effects from St. John’s Wort. Some of these side effects include headaches, nausea, dry mouth, fatigue, dizziness, and/or sensitivity to sunlight.
It is also possible for St. John’s Wort to interact with certain medications, such as birth control or antidepressants, you may already be taking, so it is wise to check with your doctor prior to taking any supplement containing Hypericum perforatum.
Things to Remember with St. John’s Wort
The overall effectiveness of St. John’s Wort depends on many variables. Where does the plant come from? Was it grown in organic conditions? Is it a tablet, powder or liquid? These are all going to affect the overall purity of the supplement. The manufacturing process of any herbal supplement can decrease the overall effectiveness of the benefits you may get from the herb. In fact, it is always best to avoid any supplement in tablet form, due to the brutal manufacturing process and because tablets are harder for the body to absorb.
Hypericum perforatum should NOT be used as a replacement to therapy. Everybody is different, please consult with your family, doctor and/or therapist, prior to taking St. John’s Wort. While it does show promise for treating symptoms of depression, it can also conteract with current medications you may be taking. So, please use caution and common sense.
Bottom line on St. John’s Wort
It is very important to do the proper research on St. John’s Wort, or any supplement you take. Most importantly, know who and where you’re buying the supplement from. Look into the Better Business Bureau records for that specific company. Try to find review’s for that product online, to see what other consumers are saying. You don’t want to ingest something that is of poor quality.
Category: Depression, Healthy Living, Natural Supplements, Stress Relief | 2 Comments











